Lupus Warning Signs: How to Recognize and Manage This Elusive Autoimmune Disease

12. Swollen Lymph Nodes

During lupus flare-ups, lymph nodes---especially in the neck, armpits, or groin---can become swollen and tender due to increased immune activity. This can add to feelings of fatigue and general discomfort.

When to act: If you notice tender lumps in these areas, particularly alongside fever, joint pain, or fatigue, it could signal a lupus flare or infection. Persistent swelling should be checked by a doctor.